What do we need to know, understand, investigate, and realize through our meditation practice? In the Anguttara Nikaya. VI, 63, the Buddha described six things that should be known in six ways. The six things to be known include desires, feelings, perceptions, taints, kamma (actions of body speech and mind), and suffering. Each can be known through their presence, conditioned origin, diversity, outcome, cessation, and way to cessation. This talk explores the structure and details of this brief sutta teaching, and proposes a practical approach to investigating the mind and our relationship with life.